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Chair(s): Fuat Saner Speaker(s): Dana Tomescu, Fuat Saner, Mark Mc Phail This webinar was hosted on October 9, 2025, at 18:00 - 19:00 CEST Cirrhosis is now recognized as a systemic disease of multiorgan failure, where the liver’s failure to maintain metabolic, circulatory, and immunologic homeostasis triggers a cascade that affects the heart, kidneys, lungs, and brain. In this modern view, liver failure is not an isolated event — it is part of a dynamic network of organ cross-talk driven by inflammation, circulatory dysregulation, and endothelial dysfunction. In the ICU and transplant setting, organ failures in cirrhosis are increasingly common and interrelated: - Acute Kidney Injury (AKI) and Hepatorenal Syndrome (HRS) reflect the interplay of circulatory dysfunction, inflammation, and renal hypoperfusion. - Portopulmonary Hypertension and Hepatopulmonary Syndrome represent distinct pulmonary vascular consequences of portal hypertension. - Cardiovascular Dysfunction adds further complexity, impairing the hemodynamic response to stress, infection, or surgery. Understanding the pathophysiological continuum between these organ failures allows for early diagnosis, targeted therapies, and better transplant outcomes.